This qualitative study problematized processes of subjectivation on people living with HIV/AIDS in the contemporaneity; it aimed to question the naturalized and universalised conceptions on the phenomena of HIV/AIDS, highlighting their historical and political nuances. Therefore, general objective was to investigate the experience of living with HIV/AIDS. It was also to analyse discovery of the HIV status, to investigate the affective-sexual lives of those people post HIV and problematize the meaning given by them to adherence to the treatment and use of medication. A post-structuralism theoretical approach was used, based on Michel Foucault´s thought. We conducted 6 semi-structured interviews with HIV/AIDS people attending a SAE (special care service for STD´s and AIDS) in Recife-PE, where subjects were accidental and deliberately chosen. The study on experience revealed HIV/Aids people facing a perspective of illness or death, regardless all time elapsed and advances acquired. As for the affective-sexual experiences, we were able to see they were mediated by matters of contamination and how AIDS as a Discourse was used by dispositif of surveillance and control for the sexuality, directly interfering on sexual practices. It is under the insignia of prevention that a sanitation order intervene engagements on love or sexual relationships, where predominates a concern of oneself or towards the others through some Techniques of the self and Ethics of Care. Finally, the issue of medication and adherence seem to work as a dispositif controlling life where medical prescriptions guided them with their health care and the population caring; those discourses seem to set foundations for a biopolitics oriented society whereas the body is transformed into a field of battles.