| dc.creator | Fernández, Pehuén | |
| dc.creator | Douthat, Walter | |
| dc.creator | Castellano, Mauro | |
| dc.creator | Cardozo, Gabriela | |
| dc.creator | Garay, Gabriela | |
| dc.creator | De Arteaga, Javier | |
| dc.creator | Chiurchiu, Carlos | |
| dc.creator | De La Fuente, Jorge | |
| dc.date | 2021 | |
| dc.date.accessioned | 2022-09-21T22:03:38Z | |
| dc.date.available | 2022-09-21T22:03:38Z | |
| dc.identifier | http://pa.bibdigital.ucc.edu.ar/3327/1/A_Fernandez_Douthat_Castellano.pdf | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12032/46181 | |
| dc.description | Cardiovascular disorders represent the leading cause of death in dialysis patients. Alterations of bone and mineral metabolism (BMM) and vascular calcifications play a fundamental role in it. The objective of this study was to evaluate the predictive role on cardiovascular mortality of the measurement of biomarkers of BMM and vascular calcifications. A prospective cohort study was performed. All prevalent patients on chronic dialysis in September 2009 at our institution, who completed the total of the complementary stud-ies, were studied. BMM biomarkers were measured (FGF 23, fetuin A, PTH, calcium and phosphorus) and the vascular calcifications were evaluated using the Kauppila and Adragao scores. Follow-up was carried out until 1/1/2019, death or transplant. Of the 30 patients included, 7 (23.3%) died due to cardiovascular causes. The follow-up time was 44.1 ± 30.4 (range = 1.4-112) months. The Adragao score was the only predictive variable of long-term cardiovascular mortality (area under the curve = 0.82; 95% CI 0.64-0.94; p < 0.001). The best cut-off point was 5 (sensitivity = 85.7%; specificity = 78.3%). It was also an independent risk factor for cardiovascular mortality adjusted for age, diabetes mellitus, coronary heart disease, aortic calcifications, time spent on dialysis and follow-up time (adjusted OR = 1.77; 95% CI = 1.06-2.96; p = 0.028). The vascular calcifications quantified from the Adragao score were the only independent predictor of long-term cardiovascular mortality. This score represents a simple, useful and superior tool to the biomarkers of BMM. | |
| dc.description | Fil: Fernández, Pehuén. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina | |
| dc.description | Fil: Fernández, Pehuén. Universidad Católica de Córdoba; Argentina | |
| dc.description | Fil: Fernández, Pehuén. Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC); Argentina | |
| dc.description | Fil: Douthat, Walter. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina | |
| dc.description | Fil: Douthat, Walter. Universidad Católica de Córdoba; Argentina | |
| dc.description | Fil: Douthat, Walter. Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC); Argentina | |
| dc.description | Fil: Castellano, Mauro. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina | |
| dc.description | Fil: Castellano, Mauro. Universidad Católica de Córdoba; Argentina | |
| dc.description | Fil: Cardozo, Gabriela. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina | |
| dc.description | Fil: Cardozo, Gabriela. Universidad Católica de Córdoba; Argentina | |
| dc.description | Fil: Garay, Gabriela. Hospital Privado Universitario de Córdoba. Laboratorio de Química Clínica; Argentina | |
| dc.description | Fil: DE ARTEAGA, Javier. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina | |
| dc.description | Fil: DE ARTEAGA, Javier. Universidad Católica de Córdoba; Argentina | |
| dc.description | Fil: Chiurchiu, Carlos. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina | |
| dc.description | Fil: Chiurchiu, Carlos. Universidad Católica de Córdoba; Argentina | |
| dc.description | Fil: DE LA FUENTE, Jorge. Hospital Privado Universitario de Córdoba. Servicio de Nefrología; Argentina | |
| dc.description | Fil: DE LA FUENTE, Jorge. Universidad Católica de Córdoba; Argentina | |
| dc.description | Fil: DE LA FUENTE, Jorge. Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC); Argentina | |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.publisher | Instituto de Investigaciones Medicas | |
| dc.relation | http://pa.bibdigital.ucc.edu.ar/3327/ | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.source | Fernández, Pehuén, Douthat, Walter, Castellano, Mauro, Cardozo, Gabriela, Garay, Gabriela, De Arteaga, Javier, Chiurchiu, Carlos and De La Fuente, Jorge (2021) Biomarkers of bone and mineral disorders (Fgf-23, fetuin-a) and vascular calcification scores as predictive tools for cardiovascular death in dialysis patients, at 10 years of follow-up[Biomarcadores del metabolismo mineral óseo (Fgf-23, fetuína-a) y calcificaciones vascu-lares como herramientas predictivas de muerte cardiovascular de pacientes en diálisis, a 10 años de seguimiento.]. Medicina (Argentina), 82 (2). pp. 191-197. ISSN 0025-7680 | |
| dc.subject | R Medicina (General) | |
| dc.title | Biomarkers of bone and mineral disorders (Fgf-23, fetuin-a) and vascular calcification scores as predictive tools for cardiovascular death in dialysis patients, at 10 years of follow-up[Biomarcadores del metabolismo mineral óseo (Fgf-23, fetuína-a) y calcificaciones vascu-lares como herramientas predictivas de muerte cardiovascular de pacientes en diálisis, a 10 años de seguimiento.] | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
