Whole seeds of Bauhinia variegata L. (Fabaceae) as an efficient biocatalyst for benzyl alcohol preparations from benzaldehydes
Autor
Demmel, Gabriela Inés
Bordón, Daniela L.
Vázquez, Ana María
Decarlini, María Florencia
Díaz Panero, Mariángeles
Rossi, Laura I.
Aimar, Mario Leandro
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Whole seeds of Bauhinia variegata L. (Fabaceae) were utilized as a biological reducer to transform benzaldehyde into benzyl alcohol. The effects of some variables such as temperature, the load of substrate and co-solvent, were established to optimize the reductive process. Utilizing the optimal reaction conditions, a laboratory-scale reaction (final concentration of the substrate: 21.2 mM) was performed to obtain benzyl alcohol (conversion: 95%; isolated yield: 49%; productivity: 1.11 g L−1 or 0.046 g L−1h−1 of benzyl alcohol). In addition, using these optimal conditions, fourteen substituted benzaldehydes were reduced, with a conversion achieved to their corresponding benzyl alcohols ranging from 62% to >99% (isolated yields from 7% to 70%). Moreover, useful building blocks by the synthesis of the drugs and important commercial products were also obtained. The scope, limitations and advantages of this new biocatalytic synthetic method are also discussed.Fil: Demmel, Gabriel I. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Bordón, Daniela L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Vázquez, Ana M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Decarlini, María F. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Díaz Panero, Mariángeles. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Rossi, Laura I. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Rossi, Laura I. Instituto de Investigaciones en Físico-Química de Córdoba (INFIQC-CONICET); Argentina
Fil: Aimar, Mario L. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina