Treatment with gonadotropin-releasing hormone analogs (GnRHa) in childhood and adolescence [Tratamiento con análogos de la hormona liberadora de gonadotrofinas (aGnRH) en niñas, niños y adolescents]
Autor
Boulgourdjian, Elisabeth M.
Alonso, Guillermo
Arcari, Andrea
Bengolea, Sonia V.
Costanzo, Mariana
D'Amato, Silvia
Keselman, Ana
Martin, Silvia
Pipman, Viviana R.
Azrak, María S.
Metadatos
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For several decades, gonadotropin releasing hormone analogs (GnRHa) are the medical treatment selected for central precocious puberty (CPP) in girls and boys. They generate an inhibition of the hypothalamus-pituitary-gonadal axis decreasing LH, FSH, estradiol and testosterone secretion and, in this way, they produce a regression of secondary sexual characters under treatment. In the last years, these analogs are also used in trans adolescents, in adolescents and young adults with oncological diseases, in some very particular situations in children with short stature and in patients with neurodevelopmental disorders. In Argentina the most commonly used formulations are triptorelin and leuprolide acetate depot forms. These analogs have proven both their efficacy and their safety. The aim of this paper is to review and update about the use of GnRHa in children and adolescents.Fil: Boulgourdjian, Elisabeth M. Hospital Italiano de Buenos Aires; Argentina
Fil: Alonso, Guillermo. Hospital Italiano de Buenos Aires; Argentina
Fil: Arcari, Andrea. Hospital de Niños Dr. Ricardo Gutiérrez; Argentina
Fil: Bengolea, Sonia V. Hospital General de Agudos Dr. Juan A. Fernández; Argentina
Fil: Costanzo, Mariana. Hospital de Pediatría S.A.M.I.C. Prof. Dr. Juan P. Garrahan; Argentina
Fil: D'Amato, Silvia. Hospital Nacional Posadas; Argentina
Fil: Keselman, Ana. Hospital de Niños Dr. Ricardo Gutiérrez; Argentina
Fil: Martin, Silvia. Universidad Católica de Córdoba. Clínica Universitaria Reina Fabiola; Argentina
Fil: Pipman, Viviana R. Hospital General de Agudos Dr. E. Tornú; Argentina
Fil: Azrak, María S. Hospital General de Agudos Dr. E. Tornú; Argentina