| dc.contributor | null | spa |
| dc.contributor.author | Duarte, Marcela; Laboratorio Producción de Tétanos. Instituto Nacional de Salud. Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá | |
| dc.contributor.author | Muñoz, Johana; Laboratorio Producción de Tétanos. Instituto Nacional de Salud. Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá | |
| dc.contributor.author | Gutiérrez, Ivón; Laboratorio Producción de Tétanos. Instituto Nacional de Salud. Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá | |
| dc.contributor.author | Arias, Janeth del Carmen; Laboratorio Producción de Tétanos. Instituto Nacional de Salud. Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá | |
| dc.date.accessioned | 2018-02-24T15:59:31Z | |
| dc.date.accessioned | 2020-04-15T18:10:24Z | |
| dc.date.accessioned | 2023-05-10T17:59:08Z | |
| dc.date.available | 2018-02-24T15:59:31Z | |
| dc.date.available | 2020-04-15T18:10:24Z | |
| dc.date.available | 2023-05-10T17:59:08Z | |
| dc.date.created | 2013-05-17 | |
| dc.identifier | http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4878 | |
| dc.identifier.issn | 2027-1352 | |
| dc.identifier.issn | 0122-7483 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12032/97248 | |
| dc.description.abstract | In order to reduce the incubation time and temperature in the Tetanic Toxin detoxification process, different times and temperature were evaluated; taking crops in process that were grown in tetanus Lab production of the National Institute of Health. To determine the exact da y of detoxification a logis tic model was established. The toxin was incubate at 4,22 and 37°C to estimate the optim temperature. Then the physical-chemical characteristics like (pH), and the biologycal characteristics (Lf/mL, unspecific, specific toxicity and antigenicy) of the toxoid were verified. The best conditions for the process are: 25 days of incubation at 37°C. With the characteristics above, yearly there is a possibility to get a profit of 1.513.350 doses that represen! $37.833.750 for the production of the Tetanic Toxin | spa |
| dc.format | PDF | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | eng | |
| dc.publisher | Pontificia Universidad Javeriana | eng |
| dc.relation.uri | http://revistas.javeriana.edu.co/index.php/scientarium/article/view/4878/3758 | |
| dc.subject | null | spa |
| dc.subject | Clostridium tétani, Detoxification, Flocculation, Tetanus, Toxin. | spa |
| dc.subject | null | spa |
| dc.title | EVALUACIÓN DEL TIEMPO Y TEMPERATURA DE INCUBACIÓN EN EL PROCESO DETOXIFICACIÓN DE UNA TOXINA TETÁNICA | spa |
