The realization of prenatal care is fundamental for the diagnosis and treatment of disease in order to prevent transmission from mother to child. Objective: To analyze the scientific production related to the Human Immunodeficiency Virus (HIV) - or human immunodeficiency virus - during the prenatal period. Method: This is an integrative review of research literature. We opted for the databases Latin American and Caribbean Science and Health (LILACS), Scientific Electronic Library Online (SciELO) and Medical Literature and Retrieval System Online (MEDLINE) in the period 2005 to 2015, considering only productions national scientific. We used a summary table as a tool for data collection and subsequent analysis, which included the following: product name, authors, place of origin of the scientific production, the study objectives, results and considerations. Results: It was found that the greatest scientific production period on the theme occurred in 2006, 2007 and 2010, and that the highest incidence regions were the south and southeast. The newspaper with the highest number of publications was the Brazilian Journal of Mother and Child Health: 26% of records. It showed that several difficulties relating to prenatal care of pregnant women with HIV, especially regarding adherence to prenatal care and treatment. The guidelines for the pregnancy, care, illness and treatment are still fragile and need further 15 research. Conclusion: Prenatal still represents a challenge for women with HIV, either by poor adherence to service or even the failure of reception towards these women. Therefore, monitoring of HIV positive pregnant women for HIV requires the multidisciplinary team specific skills and expertise to humanize the care of the binomial and ensure security in assistance.