Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. first case series in Argentina
Author
Maraschio, Martín A.
Larcher, José M Sad
Alcaraz, Alvaro
Giordano, Enzo
Reimondez, Santiago
Luján, Oscar
Iraci, Marcelo
Sereno, José L.
Priotto, Analía
Domínguez, Olga
Valle, Pablo
Abrego, Maximiliano
Rubio, Soledad
Lamberto, Cristian
Villada, Eduardo
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Objective: To develop a sheep autologous uterus transplantation (UT) program with an innovative surgical technique and assess long term uterus vitality and animal survival. Methods: A novel surgical technique consisting of the procurement of the complete uterus and the two ovaries, back table vascular reconstruction, and subsequent implantation in the same animal, performing only two arterial and two venous anastomoses. Results: Four autologous transplantations were performed; anesthesia and surgery were well tolerated by all the animals without complications. Direct observation and Doppler US performed a week after UT and laparoscopy performed three months later confirmed uterus vitality. All animals were alive more than a year after transplantation. Conclusions: Our study was the first to describe a novel surgical technique for sheep uterus autologous transplantation in Latin America, showing long-term survival and uterus vitality.Fil: Maraschio, Martín A. Hospital Privado Universitario de Córdoba. Kidney and Pancreas Transplant Program; Argentina
Fil: Larcher, José M Sad. Hospital Privado Universitario de Córdoba. Department of Obstetrics and Gynecology; Argentina
Fil: Alcaraz, Alvaro. Hospital Privado Universitario de Córdoba. Kidney and Pancreas Transplant Program; Argentina
Fil: Giordano, Enzo. Hospital Privado Universitario de Córdoba. Kidney and Pancreas Transplant Program; Argentina
Fil: Reimondez, Santiago. Hospital Privado Universitario de Córdoba. Kidney and Pancreas Transplant Program; Argentina
Fil: Luján, Oscar. Universidad Nacional de Río Cuarto. Faculty of Agronomy and Veterinary. Department of Animal Clinic; Argentina
Fil: Iraci, Marcelo. Universidad Nacional de Río Cuarto. Faculty of Agronomy and Veterinary. Department of Surgical Pathologies; Argentina
Fil: Sereno, José L. Universidad Nacional de Río Cuarto. Hospital Escuela of the Faculty of Agronomy and Veterinary; Argentina
Fil: Priotto, Analía. Hospital Privado Universitario de Córdoba. Department of Anesthesiology; Argentina
Fil: Domínguez, Olga. Hospital Privado Universitario de Córdoba. Kidney and Pancreas Transplant Program; Argentina
Fil: Valle, Pablo. Hospital Privado Universitario de Córdoba. Department of Orthopedics and Traumatology; Argentina
Fil: Abrego, Maximiliano. Hospital Privado Universitario de Córdoba. Department of Obstetrics and Gynecology; Argentina
Fil: Rubio, Soledad. Hospital Privado Universitario de Córdoba. Department of Plastic and Reconstructive Surgery; Argentina
Fil: Lamberto, Cristian. Sanagec Clinic. Imaging Department; Argentina
Fil: Villada, Eduardo. Universidad Católica de Córdoba. Veterinary Hospital; Argentina