| dc.creator | Occhieppo, Victoria Belén | |
| dc.creator | Basmadjian, Osvaldo Martín | |
| dc.creator | Marchese, Natalia Andrea | |
| dc.creator | Jaime, Andrea | |
| dc.creator | Pérez, Mariela Fernanda | |
| dc.creator | Baiardi, Gustavo Carlos | |
| dc.creator | Bregonzio, Claudia | |
| dc.date | 2022-05-03 | |
| dc.date.accessioned | 2022-09-21T22:03:35Z | |
| dc.date.available | 2022-09-21T22:03:35Z | |
| dc.identifier | http://pa.bibdigital.ucc.edu.ar/3294/1/A_Occhieppo_Basmadjian_Marchese.pdf | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12032/46148 | |
| dc.description | Schizophrenia is a chronic disease affecting 1% worldwide population, of which 30% are refractory to the available treatments: thus, searching for new pharmacological targets is imperative. The acute and repeated ketamine administration are validated preclinical models that recreate the behavioral and neurochemical features of this pathology, including the parvalbumin-expressing interneurons dysfunction. Angiotensin II, through AT1 receptors (AT1-R), modulates the dopaminergic and GABAergic neurotransmission. We evaluated the AT1-R role in the long-term neuronal activation and behavioral alterations induced by repeated ketamine administration. Adult male Wistar rats received AT1-R antagonist candesartan/vehicle (days 1–10) and ketamine/saline (days 6–10). After 14 days of drug-free, neuronal activation and behavioral analysis were performed. Locomotor activity, social interaction and novel object recognition tests were assessed at basal conditions or after ketamine challenge. Immunostaining for c-Fos, GAD67 and parvalbumin were assessed after ketamine challenge in cingulate, insular, piriform, perirhinal, and entorhinal cortices, striatum, and hippocampus. Additionally, to evaluate the AT1-R involvement in acute ketamine psychotomimetic effects, the same behavioral tests were performed after 6 days of daily-candesartan and a single-ketamine administration. We found that ketamine-induced long-lasting schizophrenia-like behavioral alterations, and regional-dependent neuronal activation changes, involving the GABAergic neurotransmission system and the parvalbumin-expressing interneurons, were AT1-R-dependent. The AT1-R were not involved in the acute ketamine psychotomimetic effects. These results add new evidence to the wide spectrum of action of ketamine and strengthen the AT1-R involvement in endurable alterations induced by psychostimulants administration, previously proposed by our group, as well as their preponderant role in the development of psychiatric pathologies. | |
| dc.description | Fil: Occhieppo, Victoria Belén. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina | |
| dc.description | Fil: Basmadjian, Osvaldo Martín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina | |
| dc.description | Fil: Marchese, Natalia Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. CONICET. Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC); Argentina | |
| dc.description | Fil: Marchese, Natalia Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica “Ranwel Caputto"; Argentina | |
| dc.description | Fil: Jaime, Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina | |
| dc.description | Fil: Pérez, Mariela Fernanda. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina | |
| dc.description | Fil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina | |
| dc.description | Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología. Instituto de Farmacología Experimental Córdoba (IFEC-CONICET); Argentina | |
| dc.description | Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Laboratorio de Neurofarmacología (IIBYT-CONICET); Argentina | |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.relation | http://pa.bibdigital.ucc.edu.ar/3294/ | |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2022.113809 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.source | Occhieppo, Victoria Belén, Basmadjian, Osvaldo Martín, Marchese, Natalia Andrea, Jaime, Andrea, Pérez, Mariela Fernanda, Baiardi, Gustavo Carlos ORCID: https://orcid.org/0000-0003-4329-4398 <https://orcid.org/0000-0003-4329-4398> and Bregonzio, Claudia (2022) Schizophrenia-like endurable behavioral and neuroadaptive changes induced by ketamine administration involve Angiotensin II AT1 receptor. Behavioural Brain Research, 425. ISSN 0166-4328 | |
| dc.subject | QD Química | |
| dc.subject | R Medicina (General) | |
| dc.title | Schizophrenia-like endurable behavioral and neuroadaptive changes induced by ketamine administration involve Angiotensin II AT1 receptor | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
