Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women
Author
de Almeida, Liz María
Cortés, Sandra
Vilensky, Marta
Valenzuela, Olivia
Cortes-Sanabria, Laura
de Souza, Mirian
Barbeito, Rafael Alonso
Abdelhay, Eliana
Artagaveytia, Nora
Daneri-Navarro, Adrian
Llera, Andrea Sabina
Müller, Bettina
Podhajcer, Osvaldo
Velazquez, Carlos
Alcoba, Elsa
Alonso, Isabel
Bravo, Alicia I.
Camejo, Natalia
Carraro, Dirce María
Castro, Mónica
Cataldi, Sandra
Cayota, Alfonso
Cerda, Mauricio
Colombo, Alicia
Crocamo, Susanne
Del Toro-Arreola, Alicia
Delgadillo-Cristerna, Raúl
Delgado, Lucía
Breitenbach, Marisa Dreyer
Fernández, Elmer Andrés
Fernández, Jorge
Fernández, Wanda
Franco-Topete, Ramón A.
Gaete, Fancy
Gómez, Jorge
Gonzalez-Ramirez, Leivy P.
Guerrero, Marisol
Gutierrez-Rubio, Susan A.
Jalfin, Beatriz
Lopez-Vazquez, Alejandra
Loria, Dora
Míguez, Silvia
Moran-Mendoza, Andrés de J.
Morgan-Villela, Gilberto
Mussetti, Carina
Nagai, Maria Aparecida
Oceguera-Villanueva, Antonio
Reis, Rui M.
Retamales, Javier
Rodriguez, Robinson
Rosales, Cristina
Salas-Gonzalez, Efrain
Segovia, Laura
Sendoya, Juan M.
Silva-Garcia, Aida A.
Viña, Stella
Zagame, Livia
Jones, Beth
Szklo, Moysés
Metadata
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Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity. Copyright © 2022 de Almeida, Cortés, Vilensky, Valenzuela, Cortes-Sanabria, de Souza, Barbeito, Abdelhay, Artagaveytia, Daneri-Navarro, Llera, Müller, Podhajcer, Velazquez, Alcoba, Alonso, Bravo, Camejo, Carraro, Castro, Cataldi, Cayota, Cerda, Colombo, Crocamo, Del Toro-Arreola, Delgadillo-Cristerna, Delgado, Breitenbach, Fernández, Fernández, Fernández, Franco-Topete, Gaete, Gómez, Gonzalez-Ramirez, Guerrero, Gutierrez-Rubio, Jalfin, Lopez-Vazquez, Loria, Míguez, Moran-Mendoza, Morgan-Villela, Mussetti, Nagai, Oceguera-Villanueva, Reis, Retamales, Rodriguez, Rosales, Salas-Gonzalez, Segovia, Sendoya, Silva-Garcia, Viña, Zagame, Jones, Szklo and United States-Latin American Cancer Research Network (US-LACRN).Fil: de Almeida, Liz Maria. Instituto Nacional de Cáncer; Brasil
Fil: Cortés, Sandra. Pontificia Universidad Católica de Chile; Chile
Fil: Vilensky, Marta. Instituto de Oncología Angel Roffo; Argentina
Fil: Valenzuela, Olivia. Universidad de Sonora; México
Fil: Cortes-Sanabria, Laura. Hospital de Especialidades, CMNO-IMSS; México
Fil: de Souza, Mirian. Instituto Nacional de Cáncer; Brasil
Fil: Barbeito, Rafael Alonso. Facultad de Medicina; Argentina
Fil: Abdelhay, Eliana. Instituto Nacional de Cáncer; Brasil
Fil: Artagaveytia, Nora. Hospital de Clínicas Manuel Quintela. Universidad de la República; Uruguay
Fil: Daneri-Navarro, Adrian. Universidad de Guadalajara; México
Fil: Llera, Andrea S. CONICET. Fundación Instituto Leloir; Argentina
Fil: Müller, Bettina. Instituto Nacional del Cáncer; Argentina
Fil: Podhajcer, Osvaldo L. CONICET. Fundación Instituto Leloir; Argentina
Fil: Velazquez, Carlos. Universidad de Sonora; México
Fil: Alcoba, Elsa. Hospital Municipal de Oncología María Curie; Argentina
Fil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; Argentina
Fil: Bravo, Alicia I. Hospital Regional de Agudos Eva Perón; Argentina
Fil: Camejo, Natalia. Hospital de Clínicas Manuel Quintela. Universidad de la República; Uruguay
Fil: Carraro, Dirce Maria. AC Camargo Cancer Center; Brasil
Fil: Castro, Mónica. Instituto de Oncología Angel Roffo; Argentina
Fil: Cataldi, Sandra. Instituto Nacional de Cáncer; Uruguay
Fil: Cayota, Alfonso. Institut Pasteur de Montevideo; Uruguay
Fil: Cerda, Mauricio. Universidad de Chile; Chile
Fil: Colombo, Alicia. Universidad de Chile; Chile
Fil: Crocamo, Susanne. Instituto Nacional de Cáncer; Brasil
Fil: Del Toro-Arreola, Alicia. Universidad de Guadalajara; México
Fil: Delgadillo-Cristerna, Raul. Hospital de Especialidades. CMNO-IMSS; México
Fil: Delgado, Lucia. Hospital de Clínicas Manuel Quintela; Uruguay
Fil: Breitenbach, Marisa Dreyer. Universidade do Estado do Rio de Janeiro; Brasil
Fil: Fernández, Elmer. Universidad Católica de Córdoba. CONICET. Centro de Investigaciones en Bioquímica Clínica e Inmunologia; Argentina
Fil: Fernández, Jorge. Instituto de Salud Pública; Chile
Fil: Fernández, Wanda. Hospital San Borja Arriarán; Chile
Fil: Franco-Topete, Ramon A. OPD Hospital Civil de Guadalajara. Universidad de Guadalajara; México
Fil: Gaete, Fancy. Hospital Luis Tisne; Chile
Fil: Gómez, Jorge. Texas A&M University; Estados Unidos
Fil: Gonzalez-Ramirez, Leivy P. Universidad de Guadalajara; México
Fil: Guerrero, Marisol. Hospital San José; Chile
Fil: Gutierrez-Rubio, Susan A. Universidad de Guadalajara; México
Fil: Jalfin, Beatriz. Hospital Regional de Agudos Eva Perón; Argentina
Fil: Lopez-Vazquez, Alejandra. Universidad de Sonora; México
Fil: Loria, Dora. Instituto de Oncología Angel Roffo; Argentina
Fil: Míguez, Silvia. Hospital Municipal de Oncología María Curie; Argentina
Fil: Moran-Mendoza, Andres de J. Hospital de Gineco-Obstetricia CMNO-IMSS; México
Fil: Morgan-Villela, Gilberto. Hospital de Especialidades. CMNO-IMSS; México
Fil: Mussetti, Carina. Registro Nacional de Cancer; Uruguay
Fil: Nagai, Maria Aparecida. Instituto de Câncer de São Paulo; Brasil
Fil: Oceguera-Villanueva, Antonio. Instituto Jalisciense de Cancerologia; México
Fil: Reis, Rui M. Hospital de Câncer de Barretos; Brasil
Fil: Retamales, Javier. Grupo Oncológico Cooperativo Chileno de Investigación; Chile
Fil: Rodriguez, Robinson. Hospital Central de las Fuerzas Armadas; Uruguay
Fil: Rosales, Cristina, Hospital Municipal de Oncología María Curie; Argentina
Fil: Salas-Gonzalez, Efrain. Hospital San José; Chile
Fil: Segovia, Laura. Hospital Barros Luco Trudeau; Chile
Fil: Sendoya, Juan M. CONICET. Fundación Instituto Leloir,; Argentina
Fil: Silva-Garcia, Aida A. OPD Hospital Civil de Guadalajara. Universidad de Guadalajara; México
Fil: Viña, Stella. Instituto de Oncología Angel Roffo; Argentina
Fil: Zagame, Livia. Instituto Jalisciense de Cancerologia; México
Fil: Jones, Beth. Yale University. Yale School of Public Health; Estados Unidos
Fil: Szklo, Moysés. Johns Hopkins University. Johns Hopkins Bloomberg School of Public Health; Estados Unidos