| dc.creator | Crescente, Juan M. | |
| dc.creator | Zavallo, Diego | |
| dc.creator | del Vas, Mariana | |
| dc.creator | Asurmendi, Sebastián | |
| dc.creator | Helguera, Marcelo | |
| dc.creator | Fernández, Elmer Andrés | |
| dc.creator | Vanzetti, Leonardo S. | |
| dc.date | 2022-12 | |
| dc.identifier | http://pa.bibdigital.ucc.edu.ar/3302/1/A_Crescente_del%20Vas_Asurmendi.pdf | |
| dc.description | Background: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs). Results: We used public small RNA and degradome libraries from Triticum aestivum to screen for microRNAs production and predict their cleavage target sites. In parallel, we also created a comprehensive wheat MITE database by identifying novel elements and compiling known ones. When comparing both data sets, we found high homology between MITEs and 14% of all the miRNAs production sites detected. Furthermore, we show that MITE-derived miRNAs have preference for targeting degradation sites with MITE insertions in the 3’ UTR regions of the transcripts. Conclusions: Our results revealed that MITE-derived miRNAs can underlay the origin of some miRNAs and potentially shape a regulatory gene network. Since MITEs are found in millions of insertions in the wheat genome and are closely linked to genic regions, this kind of regulatory network could have a significant impact on the post-transcriptional control of gene expression. | |
| dc.description | Fil: Crescente, Juan M. CONICET; Argentina | |
| dc.description | Fil: Zavallo, Diego. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina | |
| dc.description | Fil: del Vas, Mariana. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina | |
| dc.description | Fil: Asurmendi, Sebastián. CONICET. INTA. Instituto de Agrobiotecnología y Biología Molecular (IABIMO), CICVyA; Argentina | |
| dc.description | Fil: Helguera, Marcelo. EEA INTA; Argentina | |
| dc.description | Fil: Fernandez, Elmer. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas (CIDIE-CONICET); Argentina | |
| dc.description | Fil: Fernandez, Elmer. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina | |
| dc.description | Fil: Vanzetti, Leonardo S. CONICET; Argentina | |
| dc.description | Fil: Vanzetti, Leonardo S. EEA INTA; Argentina | |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.publisher | BioMed Central Ltd | |
| dc.relation | http://pa.bibdigital.ucc.edu.ar/3302/ | |
| dc.relation | https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-022-08364-4 | |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1186/s12864-022-08364-4 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.source | Crescente, Juan M., Zavallo, Diego ORCID: https://orcid.org/0000-0002-9021-2175 <https://orcid.org/0000-0002-9021-2175>, del Vas, Mariana ORCID: https://orcid.org/0000-0002-8365-8582 <https://orcid.org/0000-0002-8365-8582>, Asurmendi, Sebastián ORCID: https://orcid.org/0000-0001-9516-5948 <https://orcid.org/0000-0001-9516-5948>, Helguera, Marcelo ORCID: https://orcid.org/0000-0003-4401-8731 <https://orcid.org/0000-0003-4401-8731>, Fernández, Elmer Andrés ORCID: https://orcid.org/0000-0002-4711-8634 <https://orcid.org/0000-0002-4711-8634> and Vanzetti, Leonardo S. ORCID: https://orcid.org/0000-0002-7688-5648 <https://orcid.org/0000-0002-7688-5648> (2022) Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat. BMC Genomics, 23 (1). ISSN 1471-2164 | |
| dc.subject | Q Ciencia (General) | |
| dc.subject | QK Botánica | |
| dc.title | Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
