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Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women

dc.creatorde Almeida, Liz María
dc.creatorCortés, Sandra
dc.creatorVilensky, Marta
dc.creatorValenzuela, Olivia
dc.creatorCortes-Sanabria, Laura
dc.creatorde Souza, Mirian
dc.creatorBarbeito, Rafael Alonso
dc.creatorAbdelhay, Eliana
dc.creatorArtagaveytia, Nora
dc.creatorDaneri-Navarro, Adrian
dc.creatorLlera, Andrea Sabina
dc.creatorMüller, Bettina
dc.creatorPodhajcer, Osvaldo
dc.creatorVelazquez, Carlos
dc.creatorAlcoba, Elsa
dc.creatorAlonso, Isabel
dc.creatorBravo, Alicia I.
dc.creatorCamejo, Natalia
dc.creatorCarraro, Dirce María
dc.creatorCastro, Mónica
dc.creatorCataldi, Sandra
dc.creatorCayota, Alfonso
dc.creatorCerda, Mauricio
dc.creatorColombo, Alicia
dc.creatorCrocamo, Susanne
dc.creatorDel Toro-Arreola, Alicia
dc.creatorDelgadillo-Cristerna, Raúl
dc.creatorDelgado, Lucía
dc.creatorBreitenbach, Marisa Dreyer
dc.creatorFernández, Elmer Andrés
dc.creatorFernández, Jorge
dc.creatorFernández, Wanda
dc.creatorFranco-Topete, Ramón A.
dc.creatorGaete, Fancy
dc.creatorGómez, Jorge
dc.creatorGonzalez-Ramirez, Leivy P.
dc.creatorGuerrero, Marisol
dc.creatorGutierrez-Rubio, Susan A.
dc.creatorJalfin, Beatriz
dc.creatorLopez-Vazquez, Alejandra
dc.creatorLoria, Dora
dc.creatorMíguez, Silvia
dc.creatorMoran-Mendoza, Andrés de J.
dc.creatorMorgan-Villela, Gilberto
dc.creatorMussetti, Carina
dc.creatorNagai, Maria Aparecida
dc.creatorOceguera-Villanueva, Antonio
dc.creatorReis, Rui M.
dc.creatorRetamales, Javier
dc.creatorRodriguez, Robinson
dc.creatorRosales, Cristina
dc.creatorSalas-Gonzalez, Efrain
dc.creatorSegovia, Laura
dc.creatorSendoya, Juan M.
dc.creatorSilva-Garcia, Aida A.
dc.creatorViña, Stella
dc.creatorZagame, Livia
dc.creatorJones, Beth
dc.creatorSzklo, Moysés
dc.date2022-03-08
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/3256/1/A_Elmer_deAlmeida_Cort%C3%A9s.pdf
dc.descriptionMolecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity. Copyright © 2022 de Almeida, Cortés, Vilensky, Valenzuela, Cortes-Sanabria, de Souza, Barbeito, Abdelhay, Artagaveytia, Daneri-Navarro, Llera, Müller, Podhajcer, Velazquez, Alcoba, Alonso, Bravo, Camejo, Carraro, Castro, Cataldi, Cayota, Cerda, Colombo, Crocamo, Del Toro-Arreola, Delgadillo-Cristerna, Delgado, Breitenbach, Fernández, Fernández, Fernández, Franco-Topete, Gaete, Gómez, Gonzalez-Ramirez, Guerrero, Gutierrez-Rubio, Jalfin, Lopez-Vazquez, Loria, Míguez, Moran-Mendoza, Morgan-Villela, Mussetti, Nagai, Oceguera-Villanueva, Reis, Retamales, Rodriguez, Rosales, Salas-Gonzalez, Segovia, Sendoya, Silva-Garcia, Viña, Zagame, Jones, Szklo and United States-Latin American Cancer Research Network (US-LACRN).
dc.descriptionFil: de Almeida, Liz Maria. Instituto Nacional de Cáncer; Brasil
dc.descriptionFil: Cortés, Sandra. Pontificia Universidad Católica de Chile; Chile
dc.descriptionFil: Vilensky, Marta. Instituto de Oncología Angel Roffo; Argentina
dc.descriptionFil: Valenzuela, Olivia. Universidad de Sonora; México
dc.descriptionFil: Cortes-Sanabria, Laura. Hospital de Especialidades, CMNO-IMSS; México
dc.descriptionFil: de Souza, Mirian. Instituto Nacional de Cáncer; Brasil
dc.descriptionFil: Barbeito, Rafael Alonso. Facultad de Medicina; Argentina
dc.descriptionFil: Abdelhay, Eliana. Instituto Nacional de Cáncer; Brasil
dc.descriptionFil: Artagaveytia, Nora. Hospital de Clínicas Manuel Quintela. Universidad de la República; Uruguay
dc.descriptionFil: Daneri-Navarro, Adrian. Universidad de Guadalajara; México
dc.descriptionFil: Llera, Andrea S. CONICET. Fundación Instituto Leloir; Argentina
dc.descriptionFil: Müller, Bettina. Instituto Nacional del Cáncer; Argentina
dc.descriptionFil: Podhajcer, Osvaldo L. CONICET. Fundación Instituto Leloir; Argentina
dc.descriptionFil: Velazquez, Carlos. Universidad de Sonora; México
dc.descriptionFil: Alcoba, Elsa. Hospital Municipal de Oncología María Curie; Argentina
dc.descriptionFil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; Argentina
dc.descriptionFil: Bravo, Alicia I. Hospital Regional de Agudos Eva Perón; Argentina
dc.descriptionFil: Camejo, Natalia. Hospital de Clínicas Manuel Quintela. Universidad de la República; Uruguay
dc.descriptionFil: Carraro, Dirce Maria. AC Camargo Cancer Center; Brasil
dc.descriptionFil: Castro, Mónica. Instituto de Oncología Angel Roffo; Argentina
dc.descriptionFil: Cataldi, Sandra. Instituto Nacional de Cáncer; Uruguay
dc.descriptionFil: Cayota, Alfonso. Institut Pasteur de Montevideo; Uruguay
dc.descriptionFil: Cerda, Mauricio. Universidad de Chile; Chile
dc.descriptionFil: Colombo, Alicia. Universidad de Chile; Chile
dc.descriptionFil: Crocamo, Susanne. Instituto Nacional de Cáncer; Brasil
dc.descriptionFil: Del Toro-Arreola, Alicia. Universidad de Guadalajara; México
dc.descriptionFil: Delgadillo-Cristerna, Raul. Hospital de Especialidades. CMNO-IMSS; México
dc.descriptionFil: Delgado, Lucia. Hospital de Clínicas Manuel Quintela; Uruguay
dc.descriptionFil: Breitenbach, Marisa Dreyer. Universidade do Estado do Rio de Janeiro; Brasil
dc.descriptionFil: Fernández, Elmer. Universidad Católica de Córdoba. CONICET. Centro de Investigaciones en Bioquímica Clínica e Inmunologia; Argentina
dc.descriptionFil: Fernández, Jorge. Instituto de Salud Pública; Chile
dc.descriptionFil: Fernández, Wanda. Hospital San Borja Arriarán; Chile
dc.descriptionFil: Franco-Topete, Ramon A. OPD Hospital Civil de Guadalajara. Universidad de Guadalajara; México
dc.descriptionFil: Gaete, Fancy. Hospital Luis Tisne; Chile
dc.descriptionFil: Gómez, Jorge. Texas A&M University; Estados Unidos
dc.descriptionFil: Gonzalez-Ramirez, Leivy P. Universidad de Guadalajara; México
dc.descriptionFil: Guerrero, Marisol. Hospital San José; Chile
dc.descriptionFil: Gutierrez-Rubio, Susan A. Universidad de Guadalajara; México
dc.descriptionFil: Jalfin, Beatriz. Hospital Regional de Agudos Eva Perón; Argentina
dc.descriptionFil: Lopez-Vazquez, Alejandra. Universidad de Sonora; México
dc.descriptionFil: Loria, Dora. Instituto de Oncología Angel Roffo; Argentina
dc.descriptionFil: Míguez, Silvia. Hospital Municipal de Oncología María Curie; Argentina
dc.descriptionFil: Moran-Mendoza, Andres de J. Hospital de Gineco-Obstetricia CMNO-IMSS; México
dc.descriptionFil: Morgan-Villela, Gilberto. Hospital de Especialidades. CMNO-IMSS; México
dc.descriptionFil: Mussetti, Carina. Registro Nacional de Cancer; Uruguay
dc.descriptionFil: Nagai, Maria Aparecida. Instituto de Câncer de São Paulo; Brasil
dc.descriptionFil: Oceguera-Villanueva, Antonio. Instituto Jalisciense de Cancerologia; México
dc.descriptionFil: Reis, Rui M. Hospital de Câncer de Barretos; Brasil
dc.descriptionFil: Retamales, Javier. Grupo Oncológico Cooperativo Chileno de Investigación; Chile
dc.descriptionFil: Rodriguez, Robinson. Hospital Central de las Fuerzas Armadas; Uruguay
dc.descriptionFil: Rosales, Cristina, Hospital Municipal de Oncología María Curie; Argentina
dc.descriptionFil: Salas-Gonzalez, Efrain. Hospital San José; Chile
dc.descriptionFil: Segovia, Laura. Hospital Barros Luco Trudeau; Chile
dc.descriptionFil: Sendoya, Juan M. CONICET. Fundación Instituto Leloir,; Argentina
dc.descriptionFil: Silva-Garcia, Aida A. OPD Hospital Civil de Guadalajara. Universidad de Guadalajara; México
dc.descriptionFil: Viña, Stella. Instituto de Oncología Angel Roffo; Argentina
dc.descriptionFil: Zagame, Livia. Instituto Jalisciense de Cancerologia; México
dc.descriptionFil: Jones, Beth. Yale University. Yale School of Public Health; Estados Unidos
dc.descriptionFil: Szklo, Moysés. Johns Hopkins University. Johns Hopkins Bloomberg School of Public Health; Estados Unidos
dc.formatapplication/pdf
dc.languagespa
dc.publisherFrontiers Media S.A.
dc.relationhttp://pa.bibdigital.ucc.edu.ar/3256/
dc.relationhttps://www.frontiersin.org/articles/10.3389/fonc.2022.845527/full
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3389/fonc.2022.845527
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourcede Almeida, Liz María, Cortés, Sandra ORCID: https://orcid.org/0000-0003-3293-1419 <https://orcid.org/0000-0003-3293-1419>, Vilensky, Marta, Valenzuela, Olivia ORCID: https://orcid.org/0000-0002-4456-2107 <https://orcid.org/0000-0002-4456-2107>, Cortes-Sanabria, Laura, de Souza, Mirian, Barbeito, Rafael Alonso, Abdelhay, Eliana, Artagaveytia, Nora, Daneri-Navarro, Adrian, Llera, Andrea Sabina ORCID: https://orcid.org/0000-0002-0089-0061 <https://orcid.org/0000-0002-0089-0061>, Müller, Bettina, Podhajcer, Osvaldo ORCID: https://orcid.org/0000-0002-6512-8553 <https://orcid.org/0000-0002-6512-8553>, Velazquez, Carlos, Alcoba, Elsa, Alonso, Isabel, Bravo, Alicia I., Camejo, Natalia, Carraro, Dirce María, Castro, Mónica, Cataldi, Sandra, Cayota, Alfonso, Cerda, Mauricio ORCID: https://orcid.org/0000-0003-3447-1815 <https://orcid.org/0000-0003-3447-1815>, Colombo, Alicia, Crocamo, Susanne, Del Toro-Arreola, Alicia ORCID: https://orcid.org/0000-0002-1994-9027 <https://orcid.org/0000-0002-1994-9027>, Delgadillo-Cristerna, Raúl, Delgado, Lucía, Breitenbach, Marisa Dreyer, Fernández, Elmer Andrés ORCID: https://orcid.org/0000-0002-4711-8634 <https://orcid.org/0000-0002-4711-8634>, Fernández, Jorge, Fernández, Wanda, Franco-Topete, Ramón A., Gaete, Fancy, Gómez, Jorge, Gonzalez-Ramirez, Leivy P., Guerrero, Marisol, Gutierrez-Rubio, Susan A., Jalfin, Beatriz, Lopez-Vazquez, Alejandra, Loria, Dora, Míguez, Silvia, Moran-Mendoza, Andrés de J., Morgan-Villela, Gilberto, Mussetti, Carina, Nagai, Maria Aparecida, Oceguera-Villanueva, Antonio, Reis, Rui M., Retamales, Javier, Rodriguez, Robinson, Rosales, Cristina, Salas-Gonzalez, Efrain, Segovia, Laura, Sendoya, Juan M., Silva-Garcia, Aida A., Viña, Stella, Zagame, Livia, Jones, Beth and Szklo, Moysés (2022) Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women. Frontiers in Oncology, 12. ISSN 2234-943X
dc.subjectR Medicina (General)
dc.subjectRC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)
dc.titleSocioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo


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